How neurons regenerate lost information after damage from a neurodegenerative disease.Tanzi has developed several novel therapies for Alzheimer’s disease.

The 3-D model also made drug screening for AD faster and more cost-effective. This model was the first to recapitulate all three key AD pathological hallmarks in vitro, and first to definitively show that amyloid plaques directly cause neurofibrillary tangles. His team was the first to use human stem cells to create three-dimensional cell culture organoids of AD, dubbed “Alzheimer’s-in-a-Dish”. Tanzi discovered the first Alzheimer’s disease (AD) gene and co-discovered the two other early-onset familial AD genes. Kennedy Professor of Neurology at Harvard Medical School.ĭr. Tanzi is the Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, Co-Director of the Henry and Allison McCance Center for Brain Health, and Co-Director of the MassGeneral Institute for Neurodegenerative Disease at Massachusetts General Hospital. Rudolph Tanzi joins us on the SuperAge podcast to dive into these questions and more.

We are getting very close.Ĭan we detect neurodegenerative diseases, like Alzheimer’s disease, before irreversible damage is done? What supplements can we take to get ahead of neurodegenerative diseases? What role does loneliness play in brain health? Is there a connection between our microbiome and our brain?ĭr. The world-famous Harvard brain scientist and a musician who plays with Joe Perry and Jonny Depp, tells us what is the latest in brain research, and the very promising future for Alzheimer's prevention and treatment.

Dr rudolph tanzi super brain